Norfenfluramine
Product Specifications
UNSPSC Description
Norfenfluramine ((±)-Norfenfluramine) is a major and brain-penetrant metabolite of Fenfluramine. Norfenfluramine can interact with 5-HT transporters to release 5-HT from neurons. Norfenfluramine displays antiepileptic effects in vivo[1][2].
Target Antigen
Serotonin Transporter
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/norfenfluramine.html
Solubility
10 mM in DMSO
Smiles
NC(CC1=CC=CC(C(F)(F)F)=C1)C
Molecular Weight
203.20
References & Citations
[1]Rothman RB, et, al. (+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters. J Pharmacol Exp Ther. 2003 Jun;305(3):1191-9.|[2]Li J, et, al. Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome. Neurochem Res. 2021 Sep;46(9):2249-2261.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118010/Norfenfluramine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118010/
Clinical Information
No Development Reported
CAS Number
1886-26-6
Curated Selection
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