Norfenfluramine

Norfenfluramine ((±) -Norfenfluramine) is a major and brain-penetrant metabolite of Fenfluramine. Norfenfluramine can interact with 5-HT transporters to release 5-HT from neurons. Norfenfluramine displays antiepileptic effects in vivo[1][2].

Product Specifications

CAS Number

[1886-26-6]

Product Name Alternative

(±) -Norfenfluramine

UNSPSC

12352005

Hazard Statement

H317-H319

Target

Serotonin Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/norfenfluramine.html

Solubility

10 mM in DMSO

Smiles

NC(CC1=CC=CC(C(F)(F)F)=C1)C

Molecular Formula

C10H12F3N

Molecular Weight

203.20

Precautions

P261-P264-P272-P280-P302+P352-P305+P351+P338-P362+P364-P501

References & Citations

[1]Rothman RB, et, al. (+) -Fenfluramine and its major metabolite, (+) -norfenfluramine, are potent substrates for norepinephrine transporters. J Pharmacol Exp Ther. 2003 Jun;305 (3) :1191-9.|[2]Li J, et, al. Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome. Neurochem Res. 2021 Sep;46 (9) :2249-2261.|[3]Erenburg N, Hamed R, Shaul C, Perucca E, Bialer M. Comparative activity of the enantiomers of fenfluramine and norfenfluramine in rodent seizure models, and relationship with their concentrations in plasma and brain. Epilepsia. 2023;64 (6) :1673-1683.