Vasicinol

Vasicinol is a reversible inhibitor of sucrase (IC50: 250 μM) . Vasicinol is a HbF inducer. Vasicinol also inhibits Angiotensin-converting Enzyme (ACE) . Vasicinol is apyrroquinazoline alkaloid that can be isolated from Adhatoda vasica[1][2].

Product Specifications

CAS Number

[5081-51-6]

Product Name Alternative

6-Hydroxypeganine

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Angiotensin-converting Enzyme (ACE)

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/vasicinol.html

Solubility

10 mM in DMSO

Smiles

O[C@H]1CCN2C1=NC3=C(C=C(O)C=C3)C2

Molecular Formula

C11H12N2O2

Molecular Weight

204.23

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Gao H, et al. Inhibitory effect on α-glucosidase by Adhatoda vasica Nees. Food Chem. 2008 Jun 1;108 (3) :965-72.|[2]Tehreem S, et al. A UPLC-DAD-Based Bio-Screening Assay for the Evaluation of the Angiotensin Converting Enzyme Inhibitory Potential of Plant Extracts and Compounds: Pyrroquinazoline Alkaloids from Adhatoda vasica as a Case Study. Molecules. 2021 Nov 18;26 (22) :6971.