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Thymidine-15N2

Thymidine-15N2 is the 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].

Product Specifications

Product Name Alternative

DThyd-15N2; NSC-15N2

UNSPSC

12352005

Target

DNA/RNA Synthesis; Endogenous Metabolite; Orthopoxvirus

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thymidine-15n2.html

Purity

99.0

Solubility

10 mM in DMSO|DMSO : 50mg/mL (ultrasonic)

Smiles

O=C1[15N](C=C(C([15NH]1)=O)C)[C@]2([H])O[C@@H]([C@H](C2)O)CO

Molecular Formula

C10H14 15N2O5

Molecular Weight

244.22

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Chen G, et al. Cell Synchronization by Double Thymidine Block. Bio Protoc. 2018 Sep 5;8 (17) .; FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181 (4604) :274-5.|[3]FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181 (4604) :274-5.|[4]Izeradjene K, et al. Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independentdeletion of superantigen-reactive peripheral T cells. Int Immunol. 2001 Jan13 (1) :85-93.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-N1150S9/Thymidine-15N2-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-N1150S9/Thymidine-15N2-SDS-MedChemExpress.pdf

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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