Poloxin
Poloxin is a non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor that targets the polo-box domain, with an IC50 of appr 4.8 μM.
Product Specifications
CAS Number
321688-88-4
UNSPSC
12352005
Hazard Statement
H302, H319, H372, H410
Target
Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Poloxin.html
Purity
98.05
Solubility
DMSO : 14.29 mg/mL (ultrasonic)
Smiles
O=C(C(C(C)C)=C/1)C=C(C)C1=N/OC(C2=CC=CC=C2C)=O
Molecular Formula
C18H19NO3
Molecular Weight
297.35
Precautions
H302, H319, H372, H410
References & Citations
[1]Yuan J, et al. Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo.
 Am J Pathol. 2011 Oct;179 (4) :2091-9.|[2]Sanhaji M, et al. p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors.
 Cell Cycle. 2012 Feb 1;11 (3) :543-53.|[3]Lee KS, et al. Pinning down the polo-box domain. Chem Biol. 2008 May;15 (5) :415-6.|[4]Reindl W, et al. Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions. Chem Biol. 2008 May;15 (5) :459-66.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PLK1; PLK2; PLK3
Available Sizes
Frequently Asked Questions
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