Poloxin

Poloxin is a non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor that targets the polo-box domain, with an IC50 of appr 4.8 μM.

Product Specifications

CAS Number

[321688-88-4]

UNSPSC

12352005

Hazard Statement

H302, H319, H372, H410

Target

Polo-like Kinase (PLK)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Poloxin.html

Purity

98.05

Solubility

DMSO : 14.29 mg/mL (ultrasonic)

Smiles

O=C(C(C(C)C)=C/1)C=C(C)C1=N/OC(C2=CC=CC=C2C)=O

Molecular Formula

C18H19NO3

Molecular Weight

297.35

Precautions

H302, H319, H372, H410

References & Citations

[1]Yuan J, et al. Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo. Am J Pathol. 2011 Oct;179 (4) :2091-9.|[2]Sanhaji M, et al. p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors. Cell Cycle. 2012 Feb 1;11 (3) :543-53.|[3]Lee KS, et al. Pinning down the polo-box domain. Chem Biol. 2008 May;15 (5) :415-6.|[4]Reindl W, et al. Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions. Chem Biol. 2008 May;15 (5) :459-66.