Ro 31-7837

APTO-253 (LOR-253) hydrochloride is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 hydrochloride mediates anticancer activity via induction of Kruppel-like factor 4 (KLF4) tumor suppressor. APTO-253 hydrochloride exhibits antiarthritic activity.

Product Specifications

CAS Number

[120280-33-3]

UNSPSC

12352005

Target

Apoptosis; c-Myc

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ro-31-7837.html

Smiles

N#CC1=CC=C2C(C(C3=[N+]([O-])C=CC=C3)CC(C)(C)O2)=C1

Molecular Formula

C17H16N2O2

Molecular Weight

280.32

References & Citations

[1]Simultaneous determination of a potassium channel opener and its metabolite in rat plasma with column-switching liquid chromatography using atmospheric pressure chemical ionisation