Clorsulon (Standard)

Clorsulon (Standard) is the analytical standard of Clorsulon (HY-B0488) . This product is intended for research and analytical applications. Clorsulon (L631529; MK401) is an orally active flukicidal agent. Clorsulon inhibits glycolysis, the primary energy production pathway in flukes. Clorsulon is also a competitive inhibitor of 3-phosphoglycolate and ATP, inhibiting glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. Clorsulon can be used in studies of liver fluke (Fasciola hepatica and Fasciola gigantica) infection in calves and sheep[1][2][3][4][5][6].

Product Specifications

CAS Number

[60200-06-8]

Product Name Alternative

L631529 (Standard) ; MK401 (Standard)

UNSPSC

12352005

Target

Parasite; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Others

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/clorsulon-standard.html

Smiles

O=S(C1=C(/C(Cl)=C(Cl)\Cl)C=C(N)C(S(=O)(N)=O)=C1)(N)=O

Molecular Formula

C8H8Cl3N3O4S2

Molecular Weight

380.66

References & Citations

[1]Mrozik, H., et al., 4-amino-6- (trichloroethenyl) -1,3-benzenedisulfonamide, a new, potent fasciolicide. J Med Chem, 1977. 20 (9) : p. 1225-7.|[2]Meaney, M., et al., Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res, 2004. 92 (3) : p. 232-41.