BRD6688
BRD6688 is a selective HDAC2 inhibitor. BRD6688 increases H4K12 and H3K9 histone acetylation in primary mouse neuronal cells. BRD6688 crosses the blood brain barrier and rescues the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model[1].
Product Specifications
CAS Number
1404562-17-9
Product Name Alternative
MitoQ (mesylate); MitoQ10 (mesylate)
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/brd6688.html
Purity
98.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CCCC1)NC2=C(N)C=CC(C3=CC=NC=C3)=C2
Molecular Formula
C16H18N4O
Molecular Weight
282.34
References & Citations
[1]Wagner FF, et al. Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers. Chem Sci. 2015 Jan 1;6 (1) :804-815.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC2
Available Sizes
Frequently Asked Questions
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