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Polθ-IN-5

Polθ-IN-5 (Compound 139) is a DNA polymerase theta (Polθ) inhibitor. Polθ-IN-5 has antitumor activity[1].

Product Specifications

CAS Number

[3058636-12-4]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/polθ-in-5.html

Smiles

O=C(C1=C(C2=CC(Cl)=NC=C2OC)C=C(C)N=C1)NC3=NC4=C(CN(C4)C(C5=CN(C(F)F)N=C5)=O)S3

Molecular Formula

C23H18ClF2N7O3S

Molecular Weight

545.95

References & Citations

[1]Michael H Reutershan, et al. Semi-saturated bicyclic derivatives and related uses. WO2024211836A2. 2024-10-10.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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