Polθ-IN-5
Polθ-IN-5 (Compound 139) is a DNA polymerase theta (Polθ) inhibitor. Polθ-IN-5 has antitumor activity[1].
Product Specifications
CAS Number
[3058636-12-4]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/polθ-in-5.html
Smiles
O=C(C1=C(C2=CC(Cl)=NC=C2OC)C=C(C)N=C1)NC3=NC4=C(CN(C4)C(C5=CN(C(F)F)N=C5)=O)S3
Molecular Formula
C23H18ClF2N7O3S
Molecular Weight
545.95
References & Citations
[1]Michael H Reutershan, et al. Semi-saturated bicyclic derivatives and related uses. WO2024211836A2. 2024-10-10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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