MRK-898
MRK-898 is an orally active GABA (A) receptor modulator. MRK-898 binds to α1, α2, α3 or α5 subunit of GABA (A) receptor with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. However, α1-containing GABA (A) receptors are identified as the "sedative" and α2- and/or α3-containing receptors as the "anxiolytic" subtype (s) [1].
Product Specifications
CAS Number
461450-30-6
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mrk-898.html
Purity
99.48
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=CC(F)=CC=C1C2=C(F)C=CC(C3=CN=C4N=C(C(F)(F)F)C=CN43)=C2
Molecular Formula
C20H9F5N4
Molecular Weight
400.30
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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