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MRK-898

MRK-898 is an orally active GABA (A) receptor modulator. MRK-898 binds to α1, α2, α3 or α5 subunit of GABA (A) receptor with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. However, α1-containing GABA (A) receptors are identified as the "sedative" and α2- and/or α3-containing receptors as the "anxiolytic" subtype (s) [1].

Product Specifications

CAS Number

461450-30-6

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mrk-898.html

Purity

99.48

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC1=CC(F)=CC=C1C2=C(F)C=CC(C3=CN=C4N=C(C(F)(F)F)C=CN43)=C2

Molecular Formula

C20H9F5N4

Molecular Weight

400.30

References & Citations

[1]Atack JR. GABAA receptor subtype-selective modulators. I. α2/α3-selective agonists as non-sedating anxiolytics. Curr Top Med Chem. 2011;11 (9) :1176-202.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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