L-Hyoscyamine (sulfate hydrate)

L-Hyoscyamine sulfate hydrate, a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine sulfate hydrate is a levo-isomer to Atropine (HY-B1205) [1][2].

Product Specifications

CAS Number

[6835-16-1]

Product Name Alternative

Daturine (sulfate hydrate)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-hyoscyamine-sulfate-hydrate.html

Smiles

CN1[C@@H]2C[C@@H](OC([C@@H](C3=CC=CC=C3)CO)=O)C[C@H]1CC2.O=S(O)(O)=O.O.[0.5]

Molecular Formula

C17H23NO3.1/2H2O4S.H2O

Molecular Weight

356.44

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Lars Göran Axelsson, et al. Regulatory role of 5-HT and muscarinic receptor antagonists on the migrating myoelectric complex in rats. Eur J Pharmacol. 2003 Apr 25;467 (1-3) :211-8. |[2]Harald John, et al. Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine. Drug Test Anal. Mar-Apr 2012;4 (3-4) :194-8.