Dactolisib (hydrochloride)
Dactolisib (BEZ235) hydrochloride is an orally active, dual pan-class I PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR with IC50 of 4 nM/5 nM/7 nM/75 nM and 20.7 nM, respectively. Dactolisib hydrochloride (BEZ235) inhibits mTORC1 and mTORC2[1].
Product Specifications
CAS Number
2319647-83-9
Product Name Alternative
BEZ235 (hydrochloride) ; NVP-BEZ235 (hydrochloride)
UNSPSC
12352005
Target
Autophagy; mTOR; PI3K
Type
Reference compound
Related Pathways
Autophagy; PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dactolisib-hydrochloride.html
Smiles
CN(C1=O)C2=C(C3=CC(C4=CC5=C(N=C4)C=CC=C5)=CC=C3N=C2)N1C6=CC=C(C=C6)C(C)(C#N)C.Cl
Molecular Formula
C30H24ClN5O
Molecular Weight
506.00
References & Citations
[1]Maira SM, et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther, 2008, 7 (7), 1851-1863.|[2]Roper J, et al. The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer. PLoS One, 2011, 6 (9), e25132.|[3]Lee M, et al. Targeting PI3K/mTOR Signaling Displays Potent Antitumor Efficacy against Nonfunctioning Pituitary Adenomas. Clin Cancer Res. 2015 Jul 15;21 (14) :3204-15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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