Magic™ Membrane Protein Human RPS19BP1 (Ribosomal protein S19 binding protein 1)

AROS is a direct active regulator of SIRoom Temperature1, an NAD+-dependent deacetylase. The binding of AROS to the deacetylase upregulate SIRoom Temperature1. AROS localizes in the nucleus and the cytoplasmic ribosomes. The nuclear protein AROS (also termed 40S ribosomal protein S19-binding protein 1) enhances SIRoom Temperature1-mediated deacetylation of p53/TP53, thereby paRoom Temperatureicipating in inhibition of p53/TP53-mediated transcriptional activity. Depletion of AROS enhances p21 expression and increases both the G0/G1 population and apoptosis in response to DNA damage, whereas AROS overexpression improves cell survival.