M47
M47 is a molecular glue that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer[1].
Product Specifications
CAS Number
890808-56-7
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Cryptochrome; Molecular Glues
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m47.html
Purity
99.96
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=C(N1C2=C(CC1)C=CC=C2)C(OC3=CC=C4OC(C)(C5)C6=CC=C(C=C6)Cl)=C(C)C3=C4C5=O
Molecular Formula
C28H22ClNO4
Molecular Weight
471.93
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CRY1
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Human Kappa Light Chain / IGKC (B-Cell Marker) (KLC2886R), Biotin conjugate, 0.1mg/mL
