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M47

M47 is a molecular glue that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer[1].

Product Specifications

CAS Number

890808-56-7

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Cryptochrome; Molecular Glues

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/m47.html

Purity

99.96

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

O=C(N1C2=C(CC1)C=CC=C2)C(OC3=CC=C4OC(C)(C5)C6=CC=C(C=C6)Cl)=C(C)C3=C4C5=O

Molecular Formula

C28H22ClNO4

Molecular Weight

471.93

Precautions

H315, H319, H335

References & Citations

[1]Gul S, et, al. Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice. Nat Commun. 2022 Nov 8;13 (1) :6742.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CRY1

Available Sizes

Frequently Asked Questions

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