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(R) -DPN

(R) -DPN (compound 3) is a selective ERβ ligand with EC50s of 2.9, 0.8 nM for ERα and ERβ, respectively. (R) -DPN shows a very high affinity and potency preference for ERβ over ERα. (R) -DPN shows cytoxicity for HEC-1 and U2OS cells with EC50s of 286, 205 nM, respectively[1].

Product Specifications

CAS Number

524047-78-7

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/r-dpn.html

Solubility

10 mM in DMSO

Smiles

N#C[C@@H](C(C=C1)=CC=C1O)CC(C=C2)=CC=C2O

Molecular Formula

C15H13NO2

Molecular Weight

239.27

References & Citations

[1]Carroll VM, et al. Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptor β-selective ligands. J Med Chem. 2012 Jan 12;55 (1) :528-37.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ERα; ERβ

Frequently Asked Questions

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