(R) -DPN
(R) -DPN (compound 3) is a selective ERβ ligand with EC50s of 2.9, 0.8 nM for ERα and ERβ, respectively. (R) -DPN shows a very high affinity and potency preference for ERβ over ERα. (R) -DPN shows cytoxicity for HEC-1 and U2OS cells with EC50s of 286, 205 nM, respectively[1].
Product Specifications
CAS Number
524047-78-7
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/r-dpn.html
Solubility
10 mM in DMSO
Smiles
N#C[C@@H](C(C=C1)=CC=C1O)CC(C=C2)=CC=C2O
Molecular Formula
C15H13NO2
Molecular Weight
239.27
References & Citations
[1]Carroll VM, et al. Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptor β-selective ligands. J Med Chem. 2012 Jan 12;55 (1) :528-37.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα; ERβ
Frequently Asked Questions
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