VEGFR-2/InhA-IN-1

VEGFR-2/InhA-IN-1 is a pyrazole-based dual inhibitor of InhA-VEGFR with anti-tuberculosis and anti-angiogenic activities. VEGFR-2/InhA-IN-1 has good antibacterial activity against Mycobacterium tuberculosis H37Rv strain (MIC=6.25 μg/mL) and significantly inhibits VEGFR-2 (IC50=15.27 nM) [1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; VEGFR

Type

Reference compound

Related Pathways

Anti-infection; Protein Tyrosine Kinase/RTK

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/vegfr-2-inha-in-1.html

Smiles

O=C(NC1=CC=C(F)C=C1)NC2=CN(C3=CC=CC=C3)N=C2C4=CC=C(Cl)C=C4

Molecular Formula

C22H16ClFN4O

Molecular Weight

406.84

References & Citations

[1]Shaaban, et al. "The first-in-class pyrazole-based dual InhA-VEGFR inhibitors towards integrated antitubercular host-directed therapy." Bioorganic Chemistry 145 (2024) : 107179.