VEGFR-2/InhA-IN-1
VEGFR-2/InhA-IN-1 is a pyrazole-based dual inhibitor of InhA-VEGFR with anti-tuberculosis and anti-angiogenic activities. VEGFR-2/InhA-IN-1 has good antibacterial activity against Mycobacterium tuberculosis H37Rv strain (MIC=6.25 μg/mL) and significantly inhibits VEGFR-2 (IC50=15.27 nM) [1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; VEGFR
Type
Reference compound
Related Pathways
Anti-infection; Protein Tyrosine Kinase/RTK
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/vegfr-2-inha-in-1.html
Smiles
O=C(NC1=CC=C(F)C=C1)NC2=CN(C3=CC=CC=C3)N=C2C4=CC=C(Cl)C=C4
Molecular Formula
C22H16ClFN4O
Molecular Weight
406.84
References & Citations
[1]Shaaban, et al. "The first-in-class pyrazole-based dual InhA-VEGFR inhibitors towards integrated antitubercular host-directed therapy." Bioorganic Chemistry 145 (2024) : 107179.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
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