(R) -Nicardipine

(R) -Nicardipine ((R) -YC-93 free base) is the less active R enantiomer of Nicardipine. Nicardipine (YC-93) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure[1].

Product Specifications

CAS Number

[76093-35-1]

Product Name Alternative

(R) -YC-93 (free base)

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/r-nicardipine.html

Concentration

10mM

Purity

99.73

Solubility

DMSO : 200 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C(C)NC(C)=C(C(OCCN(C)CC2=CC=CC=C2)=O)[C@@H]1C3=CC=CC([N+]([O-])=O)=C3)OC

Molecular Formula

C26H29N3O6

Molecular Weight

479.52

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Charnet P, et al. Electrophysiological analysis of the action of nifedipine and nicardipine on myocardial fibers. Fundam Clin Pharmacol. 1987;1 (6) :413-31.