Bicarbonate-13C (sodium)

Bicarbonate-13C sodium is the 13C-labeled Sodium bicarbonate (HY-Y0756) . Sodium bicarbonate is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[87081-58-1]

UNSPSC

12352300

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Reference Standards

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/bicarbonate-13c-sodium.html

Purity

98.0

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O=[13C](O)O[Na]

Molecular Formula

13CHNaO3

Molecular Weight

85.00

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. [Content Brief]|[2]Forsythe SM, et al. Sodium bicarbonate for the treatment of lactic acidosis. Chest. 2000 Jan;117 (1) :260-7.|[3]Corral L G, et al. Antimicrobial activity of sodium bicarbonate: A research note. Journal of food science, 1988, 53 (3) : 981-982.|[4]Kawakami T, et al. Sodium bicarbonate regulates nitric oxide production in mouse macrophage cell lines stimulated with lipopolysaccharide and interferon γ. Nitric Oxide. 2018 Sep 1;79:45-50.|[5]Robey IF, et al. Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res. 2009 Mar 15;69 (6) :2260-8.|[6]Wang Y, et al. Sodium bicarbonate, an inorganic salt and a potential active agent for cancer therapy. Chinese Chemical Letters, 2021, 32 (12) : 3687-3695.|[7]Lin J, et al. Sodium Bicarbonate Decreases Alcohol Consumption in Mice. Int J Mol Sci. 2024 May 3;25 (9) :5006.