Robenidine-d8 (hydrochloride)

Robenidine-d8 (hydrochloride) is the deuterium labeled Robenidine hydrochloride. Robenidine hydrochloride is an anticoccidial agent which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively.

Product Specifications

CAS Number

[1173097-77-2]

UNSPSC

12352005

Hazard Statement

H302

Target

Bacterial; Parasite

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection

Field of Research

Infection

Purity

99.0

Solubility

10 mM in DMSO|DMSO : 6.25mg/mL (ultrasonic) |H2O : 1mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

N=C(N/N=C/C1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)N/N=C/C2=C([2H])C([2H])=C(C([2H])=C2[2H])Cl.[H]Cl

Molecular Formula

C15H6D8Cl3N5

Molecular Weight

378.71

Precautions

H302

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Abraham RJ, et al. Robenidine Analogues as Gram-Positive Antibacterial Agents. J Med Chem. 2016 Mar 10;59 (5) :2126-38.|[3]Liu C, et al. Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits. Exp Anim. 2015;64 (1) :73-9.