Human Alpha-Synuclein (A53T) Protein, Tag Free, low endotoxin (MALS verified)
Human Alpha-Synuclein (A53T), Tag Free (ALN-H5116) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1 (A53T) ) .
Product Specifications
Background
Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD) . Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
Specifications
This protein carries no "tag". The protein has a calculated MW of 14.5 kDa. The protein migrates as 15 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) .
Accession Number
P37840-1 (A53T)
Expression Region
Met 1 - Ala 140
Host
E. coli
Target
Alpha-Synuclein
Conjugation
Unconjugated
Tag
Native
Source
Human
Stability
● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.
Endotoxin
0.01 EU per μg
Purity
95%
Bioactivity
Immobilized Human Alpha-Synuclein (A53T), Tag Free (Cat. No. ALN-H5116) at 1 μg/mL (100 μL/well) can bind Anti-Synucelin alpha/beta Monoclonal Antibody with a linear range of 0.1-4 ng/mL (QC tested).
Format
Liquid
Buffer
50 mM HEPES, 100 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
14.5 kDa
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
200ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/ALN-H5116.pdf
Species
Human
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