BMS-817399
BMS-817399 is a potent, selective, and orally bioavailable CCR1 antagonist. BMS-817399 exhibits CCR1 binding affinity and chemotaxis inhibition potencies of 1 and 6 nM (IC50), respectively. BMS-817399 can be used for the research of rheumatoid arthritis[1].
Product Specifications
CAS Number
1202400-18-7
UNSPSC
12352005
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ccr1-antagonist-2.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@@](CCN1C([C@@H](C(C)C)NC(NCC(C)(O)C)=O)=O)(C(C=C2)=CC=C2Cl)C(C)(C1)C
Molecular Formula
C23H36ClN3O4
Molecular Weight
454.00
References & Citations
[1]Santella JB 3rd, et al. Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis. J Med Chem. 2014;57 (18) :7550-7564.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CCR1
Available Sizes
Frequently Asked Questions
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