8-Mercaptoguanosine

8-Mercaptoguanosine is an immunoadjuvant that affects the in vivo antibody response to the T-cell-independent antigen TNP-Ficoll. 8-Mercaptoguanosine enhances IgG1, IgG2, and IgG3 antibody responses, but has no effect on IgM antibody responses. 8-Mercaptoguanosine also enhances antibody responses to very weak antigens such as pneumococcal polysaccharide and restores antibody responses in immunodeficient xid mice that are non-reactive to TNP-Ficoll[1][2].

Product Specifications

CAS Number

[26001-38-7]

Product Name Alternative

8-Thioguanosine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/8-mercaptoguanosine.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL

Smiles

NC(NC1=O)=NC2=C1NC(N2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)=S

Molecular Formula

C10H13N5O5S

Molecular Weight

315.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Mond JJ, Hunter K, Kenny JJ, Finkelman F, Witherspoon K. 8-Mercaptoguanosine-mediated enhancement of in vivo IgG1, IgG2 and IgG3 antibody responses to polysaccharide antigens in normal and xid mice. Immunopharmacology. 1989 Nov-Dec;18 (3) :205-12.|[2]Feldbush TL, Ballas ZK. Lymphokine-like activity of 8-mercaptoguanosine: induction of T and B cell differentiation. J Immunol. 1985 May;134 (5) :3204-11.