Xanthoxyletin

Xanthoxyletin is a coumarin that can be isolated from Genus Zanthoxylum and Clausena. Xanthoxyletin has antioxidant and anti-inflammatory activities. Xanthoxyletin shows cytotoxic effects to cancer cells, and induces apoptosis and necrosis. Xanthoxyletin can be used for the research of cancer and inflammation[1][2].

Product Specifications

CAS Number

84-99-1

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/xanthoxyletin.html

Solubility

10 mM in DMSO

Smiles

O=C(O1)C=CC(C1=C2)=C(OC)C3=C2OC(C)(C)C=C3

Molecular Formula

C15H14O4

Molecular Weight

258.27

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Sanna MD, et al. Histamine H4 receptor stimulation in the locus coeruleus attenuates neuropathic pain by promoting the coeruleospinal noradrenergic inhibitory pathway. Eur J Pharmacol. 2020 Feb 5;868:172859.|[2]Jantamat P, et al. Cytotoxicity and Apoptosis Induction of Coumarins and Carbazole Alkaloids from Clausena harmandiana. Molecules. 2019 Sep 18;24 (18) :3385.