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FSEN1

FSEN1 is a potent and non-competitive FSP1 inhibitor with an IC50 value of 313 nM. FSEN1 triggers iron death in cancer cells by inhibiting FSP1. FSEN1 can be used in research of cancer[1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fsen1.html

Purity

99.56

Solubility

DMF : ≥ 1 mg/mL|DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

BrC1=CC=C(C2=NN=C3SC(CN4CCN(CC4)C5=CC=C(C=C5)OC)=CN32)C=C1

Molecular Formula

C22H22BrN5OS

Molecular Weight

484.41

References & Citations

[1]Hendricks JM, et, al. Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis. Cell Chem Biol. 2023 May 4:S2451-9456 (23) 00114-9.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-153629/FSEN1-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-153629/FSEN1-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

CAS Number

[862808-01-3]

Available Sizes

Curated Selection

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