FSEN1
FSEN1 is a potent and non-competitive FSP1 inhibitor with an IC50 value of 313 nM. FSEN1 triggers iron death in cancer cells by inhibiting FSP1. FSEN1 can be used in research of cancer[1].
Product Specifications
CAS Number
[862808-01-3]
UNSPSC
12352005
Target
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fsen1.html
Purity
99.56
Solubility
DMF : ≥ 1 mg/mL|DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
BrC1=CC=C(C2=NN=C3SC(CN4CCN(CC4)C5=CC=C(C=C5)OC)=CN32)C=C1
Molecular Formula
C22H22BrN5OS
Molecular Weight
484.41
References & Citations
[1]Hendricks JM, et, al. Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis. Cell Chem Biol. 2023 May 4:S2451-9456 (23) 00114-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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