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COX-1/2-IN-8

COX-1/2-IN-8 (compound 11f) is an orally active and potent inhibitor of COX-1 and COX-2, with IC50 values of 2.14 and 0.58 µM, respectively. COX-1/2-IN-8 displays a higher significant anti-inflammatory activity than Celecoxib.

Product Specifications

UNSPSC

12352005

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cox-1-2-in-8.html

Smiles

O=C(C1=CC=CC=C1)CSC2=NN=C(C(N3CC4=C(C=CC=C4)CC3)C5=CC=CC=C5)N2C6=CC=C(C)C=C6

Molecular Formula

C33H30N4OS

Molecular Weight

530.68

References & Citations

[1]Abo-Elmagd MI, et al. Design, synthesis and anti-inflammatory assessment of certain substituted 1,2,4-triazoles bearing tetrahydroisoquinoline scaffold as COX 1/2-inhibitors. Bioorg Chem. 2024 Sep;150:107577.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

COX-1; COX-2

Frequently Asked Questions

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