COX-1/2-IN-8
COX-1/2-IN-8 (compound 11f) is an orally active and potent inhibitor of COX-1 and COX-2, with IC50 values of 2.14 and 0.58 µM, respectively. COX-1/2-IN-8 displays a higher significant anti-inflammatory activity than Celecoxib.
Product Specifications
UNSPSC
12352005
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-1-2-in-8.html
Smiles
O=C(C1=CC=CC=C1)CSC2=NN=C(C(N3CC4=C(C=CC=C4)CC3)C5=CC=CC=C5)N2C6=CC=C(C)C=C6
Molecular Formula
C33H30N4OS
Molecular Weight
530.68
References & Citations
[1]Abo-Elmagd MI, et al. Design, synthesis and anti-inflammatory assessment of certain substituted 1,2,4-triazoles bearing tetrahydroisoquinoline scaffold as COX 1/2-inhibitors. Bioorg Chem. 2024 Sep;150:107577.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2
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