Facinicline
Facinicline (RG3487) is an orally active nicotinic α7 receptor partial agonist, with a Ki of 6 nM for α7 human nAChR. Facinicline improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride shows high affinity (antagonist) to 5-HT3Rs with a Ki value of 1.2 nM[1].
Product Specifications
CAS Number
677306-35-3
Product Name Alternative
RG3487 (free base)
UNSPSC
12352005
Target
5-HT Receptor; nAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/facinicline.html
Smiles
O=C(C1=NNC2=C1C=CC=C2)N[C@@H]3CN4CCC3CC4
Molecular Formula
C15H18N4O
Molecular Weight
270.33
References & Citations
[1]Tanya L Wallace, et al. RG3487, a Novel Nicotinic α7 Receptor Partial Agonist, Improves Cognition and Sensorimotor Gating in Rodents. J Pharmacol Exp Ther. 2011 Jan;336 (1) :242-53.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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