M1145

M1145, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM) . M1145 has an additive effect on the signal transduction of galanin[1].

Product Specifications

CAS Number

[1172089-00-7]

UNSPSC

12352209

Target

Neuropeptide Y Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/m1145.html

Purity

99.60

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

C(=O)(N1[C@H](C(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CC(C)C)=O)C)=O)CC(C)C)=O)C)=O)CCC2)CCC1)[C@H]3N(C([C@@H](NC([C@@H](NC(=O)[C@H]4N(C(CNC([C@@H](NC([C@@H](NC([C@H](CC5=CC=C(O)C=C5)NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC=6C=7C(NC6)=CC=CC7)NC([C@@H](NC(CNC([C@@H](NC(CNC([C@H](CCCNC(=N)N)N)=O)=O)CCCNC(=N)N)=O)=O)CC(N)=O)=O)=O)[C@@H](C)O)=O)CC(C)C)=O)CC(N)=O)=O)CO)=O)C)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)CCC4)[C@H](C)C)=O)CC(C)C)=O)CCC3