TAS-114
TAS-114 is an orally active dual dUTPase/dihydropyrimidine dehydrogenase (DPD) inhibitor, can improving the therapeutic efficacy of fluoropyrimidine[1].
Product Specifications
CAS Number
1198221-21-4
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tas-114.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(CCCOCN(C(N1)=O)C=CC1=O)(N[C@@H](C2=CC=CC(OC3CCCC3)=C2)C)=O
Molecular Formula
C21H29N3O6S
Molecular Weight
451.54
References & Citations
[1]Yano W, et al. TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy. Mol Cancer Ther. 2018 Aug;17 (8) :1683-1693.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![ACSL5 Mouse Monoclonal Antibody [Clone ID: OTI1C6]](https://cdn.genprice.uk/products/937/68dd18bb061270361e908c3d/imageurl/cf811884.webp)
LC402566 20 µg
Relaxin 3 receptor 1 (RXFP3) (NM_016568) Human Over-expression Lysate
Sign In for Pricing
View Details 
![Elab Fluor® 488 Anti-Mouse CD90.2/Thy1.2 Antibody[30H12]](https://cdn.genprice.uk/products/763/68dd1498061270361e7ce57e/imageurl/e-ab-f1094ul.webp)
E-AB-F1094UL-01 25 µg
Elab Fluor® 488 Anti-Mouse CD90.2/Thy1.2 Antibody[30H12]
Sign In for Pricing
View Details E-AB-F1094UL-02 100 µg
Elab Fluor® 488 Anti-Mouse CD90.2/Thy1.2 Antibody[30H12]
Sign In for Pricing
View Details 
TRC-C424210-1MG 1 mg
4-(2-Cyclohexyl-2-hydroxy-2-phenylacetoxy)-N-(4-(diethylamino)but-2-yn-1-yl)-N,N-diethylbut-2-yn-1-aminium Chloride (>90%)
Sign In for Pricing
View Details