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Gallopamil (hydrochloride)

Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist[1]. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2]. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent[3].

Product Specifications

CAS Number

16662-46-7

Product Name Alternative

Methoxyverapamil (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H332, H335

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gallopamil-hydrochloride.html

Concentration

10mM

Purity

99.15

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(OC)C(OC)=CC(C(CCCN(C)CCC2=CC(OC)=C(OC)C=C2)(C#N)C(C)C)=C1.[H]Cl

Molecular Formula

C28H41ClN2O5

Molecular Weight

521.09

Precautions

H302, H315, H319, H332, H335

References & Citations

[1]Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47 (1) :93-115.|[2]Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27 (1) :9-14.|[3]Kirchengast M, et al. Reperfusion arrhythmias in closed-chest rats: the effect of myocardial noradrenaline depletion and Ca2 (+) -antagonism. Clin Exp Pharmacol Physiol. 1991 Apr;18 (4) :217-21.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

Calcium Channel

Available Sizes

Frequently Asked Questions

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