Carbonic anhydrase inhibitor 21
Carbonic anhydrase inhibitor 21 (Compound 5h) is a selective carbonic anhydrase (hCA IX) inhibitor, with a Ki of 15.1 nM, and is highly selective against other investigated isoform. Carbonic anhydrase inhibitor 21 can be used for anticancer research[1].
Product Specifications
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/carbonic-anhydrase-inhibitor-21.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(NC(C2=CC(C(NC3=CC=C(C=C3)S(N)(=O)=O)P(OC(C)C)(OC(C)C)=O)=CC=C2)P(OC(C)C)(OC(C)C)=O)C=C1)(N)=O
Molecular Formula
C32H48N4O10P2S2
Molecular Weight
774.82
References & Citations
[1]Sobati M, et al. Sulfonamide-incorporated bis (α-aminophosphonates) as promising carbonic anhydrase inhibitors: Design, synthesis, biological evaluation, and X-ray crystallographic studies. Arch Pharm (Weinheim) . 2024 Mar 18:e2400038.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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