Carbonic anhydrase inhibitor 21

Carbonic anhydrase inhibitor 21 (Compound 5h) is a selective carbonic anhydrase (hCA IX) inhibitor, with a Ki of 15.1 nM, and is highly selective against other investigated isoform. Carbonic anhydrase inhibitor 21 can be used for anticancer research[1].

Product Specifications

UNSPSC

12352005

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/carbonic-anhydrase-inhibitor-21.html

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC=C(NC(C2=CC(C(NC3=CC=C(C=C3)S(N)(=O)=O)P(OC(C)C)(OC(C)C)=O)=CC=C2)P(OC(C)C)(OC(C)C)=O)C=C1)(N)=O

Molecular Formula

C32H48N4O10P2S2

Molecular Weight

774.82

References & Citations

[1]Sobati M, et al. Sulfonamide-incorporated bis (α-aminophosphonates) as promising carbonic anhydrase inhibitors: Design, synthesis, biological evaluation, and X-ray crystallographic studies. Arch Pharm (Weinheim) . 2024 Mar 18:e2400038.