Delgocitinib (ethanolate)
Delgocitinib ethanolate is a specific JAK inhibitor with IC50s of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively[1].
Product Specifications
CAS Number
[2064338-33-4]
Product Name Alternative
JTE-052 (ethanolate)
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/delgocitinib-ethanolate.html
Smiles
CCO.N#CCC(N1[C@]2([C@H](C1)C)CN(C3=C4C(NC=C4)=NC=N3)CC2)=O
Molecular Formula
C18H24N6O2
Molecular Weight
356.42
References & Citations
[1]Tanimoto A, et al. Pharmacological properties of JTE-052: a novel potent JAK inhibitor that suppresses various inflammatory responses in vitro and in vivo. Inflamm Res. 2015 Jan;64 (1) :41-51.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Curated Selection
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