Delgocitinib (ethanolate)

Delgocitinib ethanolate is a specific JAK inhibitor with IC50s of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively[1].

Product Specifications

CAS Number

[2064338-33-4]

Product Name Alternative

JTE-052 (ethanolate)

UNSPSC

12352005

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/delgocitinib-ethanolate.html

Smiles

CCO.N#CCC(N1[C@]2([C@H](C1)C)CN(C3=C4C(NC=C4)=NC=N3)CC2)=O

Molecular Formula

C18H24N6O2

Molecular Weight

356.42

References & Citations

[1]Tanimoto A, et al. Pharmacological properties of JTE-052: a novel potent JAK inhibitor that suppresses various inflammatory responses in vitro and in vivo. Inflamm Res. 2015 Jan;64 (1) :41-51.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 3

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