ELOVL1-IN-2
ELOVL1-IN-2 is an elongation of very long chain fatty acid 1 (ELOVL1) enzyme inhibitor, ELOVL1-IN-2 shows weak ELOVL1 inhibition (IC50=21 μM) and moderate potency in a primary cellular assay (HEK293 C26 IC50=6.7 μM) [1].
Product Specifications
CAS Number
[2761063-79-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
ELOVL
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/elovl1-in-2.html
Purity
99.82
Solubility
DMSO : 6.67 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Smiles
FC(C=C1)=CC=C1CCOC(N=C2)=CC=C2C3=CC=CN=C3
Molecular Formula
C18H15FN2O
Molecular Weight
294.32
Precautions
H302, H315, H319
References & Citations
[1]Boyd MJ, Collier PN, Clark MP, et al. Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1. J Med Chem. 2021;64 (24) :17777-17794.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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