A71378
A71378 is a selectivity CCK-A receptor agonist the IC50 values of 0.4 nM, 300 nM, and 1,200 nM for the pancreatic CCK-A, cortical CCK-B, and gastrin receptor, respectively. A71378 elicits pancreatic amylase secretion (EC50 = 0.16 nM) and ileal muscle contraction (EC50 = 3.7 nM) [1].
Product Specifications
CAS Number
[127902-33-4]
UNSPSC
12352005
Target
Cholecystokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/a71378.html
Smiles
NC([C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)N(C)C([C@H](CCCC)NC([C@@H](NC(CNC([C@H](CCCC)NC(CCC2=CC=C(C=C2)OS(=O)(O)=O)=O)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O
Molecular Formula
C48H62N8O13S
Molecular Weight
991.12
References & Citations
[1]Lin CW, et al. A71378: a CCK agonist with high potency and selectivity for CCK-A receptors. Am J Phy
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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