Mono- (2-ethylhexyl) phthalate

Mono- (2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP) . Mono- (2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD) [1].

Product Specifications

CAS Number

[4376-20-9]

Product Name Alternative

MEHP; Phthalic acid mono-2-ethylhexyl ester

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/mono-2-ethylhexyl-phthalate.html

Concentration

10mM

Purity

97.70

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(O)C1=CC=CC=C1C(OCC(CC)CCCC)=O

Molecular Formula

C16H22O4

Molecular Weight

278.35

Precautions

H315, H319

References & Citations

[1]Bai J, et al. Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells. Environ Toxicol Pharmacol. 2019 Jul;69:104-111.|[2]Tomita I, et al. Fetotoxic effects of mono-2-ethylhexyl phthalate (MEHP) in mice. Environ Health Perspect. 1986 Mar;65:249-54.