Pyruvate carboxylase
Pyruvate carboxylase is a biotin-containing enzyme that catalyzes the HCO3− and MgATP dependent carboxylation of pyruvate to form oxaloacetate. Pyruvate carboxylase plays an essential role in controlling whole-body energetics through regulation of gluconeogenesis in the liver, synthesis of fatty acids in adipocytes, and insulin secretion in pancreatic β cells[1][2].
Product Specifications
CAS Number
9014-19-1
UNSPSC
12352204
Target
Endogenous Metabolite
Type
Enzyme
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pyruvate-carboxylase.html
Solubility
10 mM in DMSO
Smiles
[Pyruvatecarboxylase]
References & Citations
[1]Jitrapakdee S, et al. Structure, mechanism and regulation of pyruvate carboxylase. Biochem J. 2008 Aug 1;413 (3) :369-87.|[2]Kiesel VA, et al. Pyruvate carboxylase and cancer progression. Cancer Metab. 2021 Apr 30;9 (1) :20.
Shipping Conditions
Room temperature
Scientific Category
Enzyme
Clinical Information
No Development Reported
Frequently Asked Questions
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