Chlorobutanol (hemihydrate)

Chlorobutanol hemihydrate is an antimicrobial agent with oral activity, also possessing preservative effects. Chlorobutanol hemihydrate exhibits resistance to a variety of Gram-positive and Gram-negative bacteria, as well as several fungal spores and fungi, and is widely used in the food and cosmetics industries[1][2][3][4][5].

Product Specifications

CAS Number

[6001-64-5]

UNSPSC

12352211

Hazard Statement

H302

Target

Antibiotic; Bacterial; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/chlorobutanol-hemihydrate.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(O)(C)C(Cl)(Cl)Cl.O.[1/2]

Molecular Formula

C4H7Cl3O.1/2H2O

Molecular Weight

186.46

Precautions

H302

References & Citations

[1]Smoak IW, et al. Chlorobutanol: maternal serum levels and placental transfer in the mouse. Vet Hum Toxicol. 1997 Oct;39 (5) :287-90.|[2]Friesen WT, et al. The antibacterial stability of chlorobutanol stored in polyethylene bottles. Am J Hosp Pharm. 1971 Jul;28 (7) :507-12.|[3]Jeong D, et al. In Vivo Evaluation of the Oral Toxicity of the Chlorobutanol. Toxics. 2022 Jan 7;10 (1) :24.|[4]Habara Y, et al. Dual effects of chlorobutanol on secretory response and intracellular Ca2+ dynamics in isolated pancreatic acini of the rat. Br J Pharmacol. 1993 Jul;109 (3) :685-92.|[5]Hadhoum N, et al. Synthesis, Physicochemical Characterization and Study of the Antimicrobial Activity of Chlorobutanol[J]. 2019.