Delavirdine (mesylate)

Delavirdine (U 90152) mesylate is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) . Delavirdine mesylate selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26 μM) over DNA polymerase α (IC50=440 μM) and polymerase δ (IC50>550 μM) . Delavirdine mesylate is an inhibitor of HIV-1 replication and can can be used for the study of AIDs[1].

Product Specifications

CAS Number

[147221-93-0]

Product Name Alternative

U 90152 (mesylate) ; BHAP-U 90152 (mesylate)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

HIV; Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Delavirdine-mesylate.html

Purity

98.65

Solubility

DMSO : ≥ 40.3 mg/mL

Smiles

O=S(NC1=CC=C(NC(C(N2CCN(C3=C(NC(C)C)C=CC=N3)CC2)=O)=C4)C4=C1)(C)=O.O=S(O)(C)=O

Molecular Formula

C23H32N6O6S2

Molecular Weight

552.67

Precautions

H315, H319, H335

References & Citations

[1]Dueweke TJ, et al. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob Agents Chemother. 1993 May;37 (5) :1127-31.|[2]Mayland Chang, et al. Metabolism of the HIV-1 Reverse Transcriptase Inhibitor Delavirdine In Mice. Research Article