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DBCO-β-Glu-PEG12-Exatecan

DBCO-β-Glu-PEG12-Exatecan (Compound 107) is an inhibitor for topoisomerase I. DBCO-β-Glu-PEG12-Exatecan can be used as a Drug-Linker Conjugate for ADC molecule[1].

Product Specifications

CAS Number

[3025107-83-6]

UNSPSC

12352005

Target

Drug-Linker Conjugates for ADC; Topoisomerase

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbco-β-glu-peg12-exatecan.html

Purity

98.63

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(OCC(C=C1)=CC(CNC(CCNC([C@H](CNC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)NC(CCCCC(N2C3=CC=CC=C3C#CC4=CC=CC=C4C2)=O)=O)=O)=O)=C1O[C@@H]([C@@H]([C@H]5O)O)O[C@@H]([C@H]5O)C(O)=O)N[C@@H]6C(C7=C8CC6)=C(CN9C%10=CC([C@@]%11(O)CC)=C(COC%11=O)C9=O)C%10=NC7=CC(F)=C8C

Molecular Formula

C92H117FN8O30

Molecular Weight

1833.95

References & Citations

[1]BAJJURI K, et al., β-GLUCURONIDE LINKER-PAYLOADS, PROTEIN CONJUGATES THEREOF, AND METHODS THEREOF. WO2024006272.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Camptothecins

Available Sizes

Curated Selection

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