ERK-IN-4

ERK-IN-4 is an ERK inhibitor binds preferentially to ERK2 with a Kd of 5 μM. ERK-IN-4 specificity inhibits ERK Rsk-1 and Elk-1 phosphorylation. ERK-IN-4 has little effect on ERK protein phosphorylation by its upstream activator MEK1/2[1].

Product Specifications

CAS Number

[1049738-54-6]

UNSPSC

12352005

Target

ERK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/erk-in-4.html

Purity

99.61

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C(N(CCN)C/1=O)SC1=C/C2=CC=C(OCC)C=C2.[H]Cl

Molecular Formula

C14H17ClN2O3S

Molecular Weight

328.81

References & Citations

[1]Chad N Hancock, et al. Identification of novel extracellular signal-regulated kinase docking domain inhibitors. J Med Chem. 2005 Jul 14;48 (14) :4586-95.