Atiprimod (dimaleate)
Atiprimod (Azaspirane) (dimaleate) is a STAT3 inhibitor with antitumor, anti-inflammatory, and anti-angiogenic activities. Atiprimod blocks the signaling pathways of IL-6 and VEGF by inhibiting the phosphorylation of signal transducer and activator of STAT3. Atiprimod blocks the JAK-STAT signaling pathway by inhibiting the phosphorylation of JAK2 and JAK3. Atiprimod also inhibits cell proliferation, induces cell cycle arrest, and induces autophagy and apoptosis. Atiprimod triggers persistent ER stress-mediated apoptosis in breast cancer cells by activating the PERK/eIF2α/ATF4/CHOP axis and inhibiting the nuclear translocation of STAT3/NF-κB. Atiprimod shows great anti-tumor activities in tumor xenograft mouse models. Atiprimod can be used for the study of pituitary adenoma, breast cancer, multiple myeloma and acute myeloid leukemia (AML) [1][2][3][4][5][6].
Product Specifications
CAS Number
183063-72-1
Product Name Alternative
Azaspirane (dimaleate) ; SKF 106615-12 (dimaleate) ; SKF 106615A12 (dimaleate)
UNSPSC
12352005
Target
Apoptosis; Atg8/LC3; Autophagy; Caspase; Interleukin Related; JAK; p62; Reactive Oxygen Species (ROS) ; STAT
Type
Reference compound
Related Pathways
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/atiprimod-dimaleate.html
Smiles
CCCC(CC1)(CCC)CCC21CCN(CCCN(CC)CC)C2.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O
Molecular Formula
C30H52N2O8
Molecular Weight
568.74
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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