Roundabout homolog 1, ROBO1

Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development. Defects in ROBO1 may be a cause of breast and lung cancer. ROBO1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line.

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

1. Brose K., Bland K.S., Wang K.H., Arnott D., Henzel W., Goodman C.S., Tessier-Lavigne M., Kidd T.; Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.; Cell 96:795-806(1999). 2. Dallol A., Forgacs E., Martinez A., Sekido Y., Walker R., Kishida T., Rabbitts P., Maher E.R., Minna J.D., Latif F.; Tumour specific promoter region methylation of the Human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in Human cancers.; Oncogene 21:3020-3028(2002).