DBI-2
DBI-2 is an AMPK activator targeting mitochondrial complex I. DBI-2 disrupts the OXPHOS process, and reduces ATP generation in mitochondria. DBI-2 inhibits the proliferation of colorectal cancer (CRC) cells[1].
Product Specifications
CAS Number
[2939087-00-8]
UNSPSC
12352005
Target
AMPK; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dbi-2.html
Smiles
CN(CCN(C)CCCCOC1=CC=C2C(OC=C(C3=CC=C(Br)C=C3)C2=O)=C1)C
Molecular Formula
C24H29BrN2O3
Molecular Weight
473.40
References & Citations
[1]Lichao Guo, et al. Inhibition of Carbohydrate Metabolism Potentiated by the Therapeutic Effects of Oxidative Phosphorylation Inhibitors in Colon Cancer Cells. Cancers (Basel) . 2024 Apr 2;16 (7) :1399.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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