DBI-2

DBI-2 is an AMPK activator targeting mitochondrial complex I. DBI-2 disrupts the OXPHOS process, and reduces ATP generation in mitochondria. DBI-2 inhibits the proliferation of colorectal cancer (CRC) cells[1].

Product Specifications

CAS Number

[2939087-00-8]

UNSPSC

12352005

Target

AMPK; Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbi-2.html

Smiles

CN(CCN(C)CCCCOC1=CC=C2C(OC=C(C3=CC=C(Br)C=C3)C2=O)=C1)C

Molecular Formula

C24H29BrN2O3

Molecular Weight

473.40

References & Citations

[1]Lichao Guo, et al. Inhibition of Carbohydrate Metabolism Potentiated by the Therapeutic Effects of Oxidative Phosphorylation Inhibitors in Colon Cancer Cells. Cancers (Basel) . 2024 Apr 2;16 (7) :1399.