N, N'-Diacetyl-L-cystine

N, N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N, N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N, N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits[1][2].

Product Specifications

CAS Number

[5545-17-5]

Product Name Alternative

DiNAC; (Ac-Cys-OH) 2

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/n-n-diacetyl-l-cystine.html

Concentration

10mM

Purity

99.06

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)[C@H](CSSC[C@@H](C(O)=O)NC(C)=O)NC(C)=O

Molecular Formula

C10H16N2O6S2

Molecular Weight

324.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Wågberg M, et al. N, N'-diacetyl-L-cystine (DiNAC), the disulphide dimer of N-acetylcysteine, inhibits atherosclerosis in WHHL rabbits: evidence for immunomodulatory agents as a new approach to prevent atherosclerosis. J Pharmacol Exp Ther. 2001 Oct;299 (1) :76-82.|[2]Särnstrand B, et al. N, N'-Diacetyl-L-cystine-the disulfide dimer of N-acetylcysteine-is a potent modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. J Pharmacol Exp Ther. 1999 Mar;288 (3) :1174-84.