3,4,5-Trimethoxycinnamic acid

3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals[1][2]. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].

Product Specifications

CAS Number

[90-50-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; GABA Receptor

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/3,4,5-Trimethoxycinnamic_acid.html

Purity

99.90

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(OC)C(OC)=CC(/C=C/C(O)=O)=C1

Molecular Formula

C12H14O5

Molecular Weight

238.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Kawashima K, et al. Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji) . Biol Pharm Bull. 2004 Aug;27 (8) :1317-9.|[2]Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36 (10) :1244-51.