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Poneratoxin

Poneratoxin is the modulator for voltage-gated sodium channel (NaV, EC50 for NaV1.6 and NaV1.7 is 97 nM and 2.3 µM), that lowers the voltage threshold for activation and inhibits the inactivation of channels, enhances the excitability of neurons, and leads to the transmission of pain signals[1].

Product Specifications

CAS Number

137084-94-7

UNSPSC

12352209

Target

Sodium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/poneratoxin.html

Solubility

10 mM in DMSO

Smiles

C(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]2N(C([C@@H](NC([C@H](CC3=CC=CC=C3)N)=O)CC(C)C)=O)CCC2)CC(C)C)=O)CC(C)C)=O)[C@H](CC)C)=O)CC(C)C)=O)=O)CO)=O)CC(C)C)=O)CC(C)C)=O)CCSC)=O)[C@@H](C)O)=O)CCC1)N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC5=CN=CN5)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)CCC(N)=O)=O)C)=O)CC(O)=O)=O)=O)[C@H](CC)C)=O)C)=O)CCC(N)=O)=O)[C@H](CC)C)=O)[C@H](C)C)=O)CCC4

Molecular Formula

C129H215N33O31S

Molecular Weight

2756.35

References & Citations

[1]Robinson SD, et al., Ant venoms contain vertebrate-selective pain-causing sodium channel toxins. Nat Commun. 2023 May 23;14 (1) :2977.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Citation 01

Bioorg Med Chem. 2025 Oct 9:132:118436.|Sci Rep. 2025 Jul 16;15 (1) :25854.|PLoS Biol. 2025 Nov 24;23 (11) :e3003513.

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